Cumulative blood loss >=1000 mL or bleeding with signs of hypovolemia within 24 h of delivery.
Also known as: PPH, postpartum hemorrhage, uterine atony, obstetric hemorrhage
Overview
ACOG (2017): cumulative blood loss of >=1000 mL OR blood loss accompanied by signs/symptoms of hypovolemia within 24 hours after the birth process, regardless of delivery route. Primary PPH occurs within 24 h; secondary (late) PPH between 24 h and 12 weeks postpartum.
Epidemiology
Complicates ~4% of vaginal and ~6% of cesarean deliveries. Leading cause of maternal mortality worldwide; major contributor to severe maternal morbidity in the US.
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Uterine inversion (excessive cord traction with fundal placenta)
Pathophysiology
Normal hemostasis after delivery depends on rapid uterine contraction compressing the spiral arteries. Failure of any of the '4 Ts' — Tone (atony), Trauma (laceration/rupture), Tissue (retained products, accreta), Thrombin (coagulopathy) — produces hemorrhage. Atony accounts for ~80% of cases.
Clinical presentation
Symptoms
Heavy vaginal bleeding immediately or shortly after delivery
Lightheadedness, weakness, syncope
Lower abdominal pain (rupture, inversion)
Signs / physical exam
Tachycardia and hypotension (often late, particularly in young women with high cardiac reserve)
Boggy uterus = atony; firm uterus with bleeding = laceration
Cool, clammy skin; pallor; oliguria
Differential diagnosis
Uterine atony — Soft, boggy uterus above the umbilicus; bleeding heavy and continuous; responds to bimanual massage
Genital tract laceration — Firm, well-contracted uterus with continued bright red bleeding; visualize on speculum exam
Retained placenta or fragments — Incomplete placenta on inspection; ultrasound shows echogenic material in cavity
Placenta accreta/increta/percreta — Failure of placental separation; risk with prior cesarean and placenta previa
Uterine inversion — Sudden hemorrhage with severe lower abdominal pain after cord traction; non-palpable fundus, mass in vagina
Uterine rupture — Severe pain, loss of fetal station, hemodynamic collapse; classically with prior cesarean and induction
Clinical: cumulative blood loss >=1000 mL or signs of hypovolemia after delivery. Quantitative blood loss (QBL) is preferred over visual estimation.
Labs
Type and crossmatch; CBC, fibrinogen, PT/PTT, INR
ABG/lactate, BMP, ionized calcium
Activate massive transfusion protocol early when ongoing brisk bleeding
Imaging
Bedside ultrasound: retained products (echogenic material in cavity)
Inspection of placenta for completeness; examination under anesthesia if needed
Diagnostic algorithm
The 4 Ts
Cause
Approximate Frequency
Tone
Uterine atony
70-80%
Trauma
Lacerations, rupture, inversion
15-20%
Tissue
Retained placenta, accreta
5-10%
Thrombin
Coagulopathy (DIC, inherited, anticoagulation)
1-2%
The '4 Ts' framework for causes of postpartum hemorrhage.
Treatment
First-line
Call for help; large-bore IV access x 2; crystalloid resuscitation; activate massive transfusion protocol with balanced ratio (e.g., 1:1:1 PRBC:FFP:platelets) for severe hemorrhage
Identify cause using '4 Ts': Tone, Trauma, Tissue, Thrombin
Bimanual uterine massage and compression
Uterotonics in stepwise fashion:
- Oxytocin 10-40 units in 500-1000 mL IV (first-line; routinely given prophylactically)
- Methylergonovine 0.2 mg IM every 2-4 h (contraindicated in hypertension/preeclampsia)
- Carboprost (15-methyl PGF2-alpha, Hemabate) 0.25 mg IM every 15-90 min (contraindicated in asthma)
- Misoprostol 600-1000 mcg sublingual, oral, or rectal
Tranexamic acid 1 g IV (within 3 h of birth) reduces death from bleeding (WOMAN trial); can repeat once after 30 min if bleeding continues
Repair lacerations; explore uterine cavity and manually remove retained products if present
Hysterectomy — definitive treatment; do not delay in unstable patients or with accreta spectrum
Uterine inversion
Halt uterotonics, manually replace uterus, then restart uterotonics; tocolytic (terbutaline, nitroglycerin, or general anesthesia) to relax uterus may be needed
Second-line / adjunct
Recombinant factor VIIa is rarely used for refractory coagulopathic hemorrhage after correction of underlying deficits
Cell saver use is acceptable in obstetric hemorrhage when appropriate
Postpartum venous thromboembolism (rebound thrombosis), Asherman syndrome (from aggressive curettage), hysterectomy with loss of fertility
Maternal death
PANCE pearls
Active management of the third stage of labor (prophylactic oxytocin, controlled cord traction, uterine massage) reduces PPH by ~60% and is standard of care.
Tranexamic acid (TXA) should be given within 3 hours of birth for established PPH; the WOMAN trial showed reduced death from bleeding without increased thromboembolism.
Methylergonovine is contraindicated in HTN/preeclampsia (severe hypertensive crisis); carboprost is contraindicated in asthma (bronchospasm).
Sheehan syndrome should be considered in any postpartum woman with hypotension followed by failure to lactate, fatigue, or amenorrhea.
Placenta accreta should be anticipated in patients with prior cesarean and current placenta previa — plan for cesarean hysterectomy at a tertiary center.
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