Confusable diagnoses · PANCE / PANRE

Generalized Anxiety Disorder vs Panic Disorder

Generalized Anxiety Disorder and Panic Disorder are easy to mix up on the boards. Here's a side-by-side comparison — presentation, workup, imaging, and first-line treatment — drawn from our full outlines.

Generalized Anxiety Disorder vs Panic Disorder at a glance

  • Generalized Anxiety Disorder: Excessive, hard-to-control worry about multiple domains >=6 months with physical and cognitive symptoms.
  • Panic Disorder: Recurrent unexpected panic attacks plus >=1 month of worry about future attacks or maladaptive behavior change.

Try two board-style questions on Generalized Anxiety Disorder vs Panic Disorder

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Question 1PsychiatryMedium
A 29-year-old graduate student reports 8 months of restlessness, fatigue, irritability, muscle tension, and trouble falling asleep. Her GAD-7 score is 16. She denies substance use, and thyroid studies and physical examination are normal. Which additional history finding would most strongly support generalized anxiety disorder over panic disorder?
  • APersistent fear of being scrutinized while speaking in class
  • BUncontrollable worry about school, money, and health daily
  • CAvoidance of buses and crowds unless a friend goes along
  • DAbrupt surges of fear that peak within several minutes
Reveal answer & full explanation
Correct answer: B — Uncontrollable worry about school, money, and health daily
  • APersistent fear of being scrutinized while speaking in class
  • BUncontrollable worry about school, money, and health daily✓
  • CAvoidance of buses and crowds unless a friend goes along
  • DAbrupt surges of fear that peak within several minutes

Why Uncontrollable worry about school, money, and health daily is correct

  • The GAD-7 is a severity measure, not a diagnostic instrument; a score of 16 indicates severe anxiety symptoms and obligates the clinician to take a history that assigns those symptoms to a specific disorder.
  • Generalized anxiety disorder requires excessive, difficult-to-control worry about multiple domains occurring more days than not for at least 6 months, plus at least three of six associated symptoms including restlessness, fatigue, irritability, muscle tension, concentration difficulty, and sleep disturbance.
  • Uncontrollable worry about school, money, and health daily — the multi-domain, persistent, hard-to-control worry that defines GAD and separates it from every episodic anxiety disorder; correct.

Why the others are wrong

  • Abrupt surges of fear that peak within several minutes — the defining feature of a panic attack, and when attacks are recurrent, unexpected, and followed by a month of worry about further attacks, they define panic disorder instead.
  • Persistent fear of being scrutinized while speaking in class — social anxiety disorder, in which the fear is bounded by performance and social evaluation rather than diffuse.
  • Avoidance of buses and crowds unless a friend goes along — agoraphobia, defined by fear of situations where escape or help would be difficult.

Both her chronic course and the multi-domain content of the worry, obtained purely by history, make the distinction; the somatic symptoms themselves overlap across all four conditions and cannot discriminate.

Question 2PsychiatryMedium
A 40-year-old man reports recurrent panic attacks and avoids driving because he fears being unable to escape if symptoms occur. Which of the following is the most appropriate first-line long-term pharmacotherapy?
  • AAlprazolam
  • BPropranolol
  • CSertraline
  • DHydroxyzine
Reveal answer & full explanation
Correct answer: C — Sertraline
  • AAlprazolam
  • BPropranolol
  • CSertraline✓
  • DHydroxyzine

Why Sertraline is correct

  • Panic disorder with situational avoidance is treated long-term with an SSRI plus cognitive behavioral therapy.
  • Sertraline lowers attack frequency and anticipatory anxiety without dependence, making it the preferred maintenance agent.
  • It addresses the underlying disorder rather than only aborting acute attacks.

Why the others are wrong

  • Alprazolam — fast relief but tolerance, dependence, and rebound anxiety make benzodiazepines poor long-term monotherapy (rapid-relief trap).
  • Propranolol — blunts peripheral autonomic symptoms such as tremor and palpitations but does not prevent panic attacks or reduce the anticipatory avoidance described here.
  • Hydroxyzine — a nonaddictive as-needed anxiolytic without evidence for maintenance control of panic disorder (PRN-versus-maintenance trap).
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Side-by-side comparison

FeatureGeneralized Anxiety DisorderPanic Disorder
At a glanceExcessive, hard-to-control worry about multiple domains >=6 months with physical and cognitive symptoms.Recurrent unexpected panic attacks plus >=1 month of worry about future attacks or maladaptive behavior change.
Classic presentationGAD-7 >=10 supports moderate-or-greater severity; >=15 severe.; Excessive worry across multiple domains (work, finances, family, health) most days for >=6 months; Difficulty controlling the worry; >=3 of: restlessness, easy fatigability, difficulty concentrating, irritability, muscle tension, sleep disturbance (only 1 needed in…Panic attack: >=4 of 13 symptoms peaking within minutes — palpitations, sweating, trembling, dyspnea, choking sensation, chest pain, nausea, dizziness, chills/heat, paresthesias, derealization/depersonalization, fear of losing control, fear of dying; Attacks last 10-30 minutes; afterwards, patients feel exhausted; Anticipatory anxiety…
Workup / key labsDSM-5-TR: Excessive anxiety and worry occurring more days than not for >=6 months about multiple events/activities; difficulty controlling worry; >=3 of 6 associated symptoms (restlessness, fatigue, poor concentration, irritability, muscle tension, sleep disturbance); causes significant distress/impairment; not attributable to substance…DSM-5-TR: Recurrent unexpected panic attacks AND >=1 month of one or both: (a) persistent concern about additional attacks or their consequences, (b) significant maladaptive change in behavior related to attacks. Not attributable to substance/medical condition and not better explained by another disorder. Agoraphobia is a separate,…
ImagingNot routinely indicatedNot routinely required; CT/CTA only if PE, dissection, or other organic cause suspected
First-line treatmentCognitive behavioral therapy (CBT) — first-line; comparable to medication and durable benefits; SSRI — sertraline, escitalopram, paroxetine (titrate gradually to avoid initial anxiogenic effect); SNRI — venlafaxine XR, duloxetine; Combination of CBT + medication for moderate-to-severe symptoms; Sleep, exercise, caffeine reduction,…Cognitive behavioral therapy — interoceptive exposure targets fear of bodily sensations; graded in vivo exposure to avoided situations is added for agoraphobia — strongest evidence base; SSRI — sertraline, escitalopram, paroxetine, fluoxetine (start at low dose to avoid initial activation); SNRI — venlafaxine XR; Patient education:…

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Educational use only. This outline is a study aid for PA students and is not medical advice or a substitute for clinical judgment. FirstPassPA is an independent study tool and is not affiliated with, endorsed by, or sponsored by NCCPA or PAEA. PANCE® and PANRE® are registered trademarks of the National Commission on Certification of Physician Assistants; End of Rotation™ is a program of the Physician Assistant Education Association.