Confusable diagnoses · PANCE / PANRE

Borderline Personality Disorder vs Antisocial Personality Disorder

Borderline Personality Disorder and Antisocial Personality Disorder are easy to mix up on the boards. Here's a side-by-side comparison — presentation, workup, imaging, and first-line treatment — drawn from our full outlines.

Borderline Personality Disorder vs Antisocial Personality Disorder at a glance

  • Borderline Personality Disorder: Pervasive instability of relationships, self-image, affect, and marked impulsivity beginning in early adulthood.
  • Antisocial Personality Disorder: Pervasive disregard for and violation of the rights of others since age 15, with conduct disorder before age 15.
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Side-by-side comparison

FeatureBorderline Personality DisorderAntisocial Personality Disorder
At a glancePervasive instability of relationships, self-image, affect, and marked impulsivity beginning in early adulthood.Pervasive disregard for and violation of the rights of others since age 15, with conduct disorder before age 15.
Classic presentation>=5 of 9 DSM-5-TR criteria: frantic efforts to avoid real/imagined abandonment; unstable intense relationships alternating idealization and devaluation;…>=3 of 7 criteria since age 15: failure to conform to social/legal norms (arrests); deceitfulness (lying, conning); impulsivity; irritability and…
Workup / key labsDSM-5-TR: A pervasive pattern of instability of interpersonal relationships, self-image, and affects, and marked impulsivity, beginning by early adulthood and…DSM-5-TR: (A) >=3 of 7 antisocial criteria since age 15; (B) >=18 years old; (C) Conduct disorder with onset before age 15; (D) Antisocial behavior not…
ImagingNot routinely indicatedNot routinely indicated
First-line treatmentEvidence-based psychotherapy is primary — dialectical behavior therapy (DBT), mentalization-based therapy (MBT), transference-focused psychotherapy (TFP),…Treat comorbid substance use disorder — often the most modifiable contributor to behavior; Treat comorbid depression, anxiety, and ADHD; avoid stimulants and…

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Educational use only. This outline is a study aid for PA students and is not medical advice or a substitute for clinical judgment. FirstPassPA is an independent study tool and is not affiliated with, endorsed by, or sponsored by NCCPA. PANCE® and PANRE® are registered trademarks of the National Commission on Certification of Physician Assistants.