EENT · PANCE / PANRE

Peritonsillar Abscess (Quinsy)

Pus collection between tonsil capsule and pharyngeal constrictor — requires drainage plus antibiotics.

Also known as: peritonsillar abscess, PTA, quinsy

Overview

Suppurative collection in the potential space between the palatine tonsil capsule and the superior pharyngeal constrictor muscle. The most common deep neck space infection in adolescents and young adults.

Epidemiology

Annual incidence ~30/100,000 in adolescents and young adults; peak ages 15-30. Often follows acute tonsillitis or pharyngitis. Smoking and prior PTA increase risk.

Try a board-style Peritonsillar Abscess question

Real questions from the FirstPassPA bank, with the full explanation. Pick an answer — no signup, no email.

Question 1EENTEasy
A 19-year-old man has 5 days of sore throat that is now much worse on the right, with pain radiating to the right ear and difficulty swallowing his own saliva. He was started on amoxicillin 3 days ago with no improvement. Temperature is 38.7 C and heart rate is 104/min. His voice is muffled and he is drooling slightly into a cup. He is sitting comfortably and is not stridorous. Which physical examination finding is most likely to be present?
  • AA swollen cherry-red epiglottis with a normal oropharynx
  • BGrey tonsillar exudate with posterior cervical adenopathy
  • CA bulging posterior pharyngeal wall with neck stiffness
  • DTender induration beneath the jaw with a raised tongue
  • EDeviation of the uvula toward the left with trismus
Reveal answer & full explanation
Correct answer: E — Deviation of the uvula toward the left with trismus
  • AA swollen cherry-red epiglottis with a normal oropharynx
  • BGrey tonsillar exudate with posterior cervical adenopathy
  • CA bulging posterior pharyngeal wall with neck stiffness
  • DTender induration beneath the jaw with a raised tongue
  • EDeviation of the uvula toward the left with trismus✓

Why Deviation of the uvula toward the left with trismus is correct

  • Peritonsillar abscess is the most common deep neck space infection in adolescents and young adults and typically develops as a suppurative complication of tonsillitis that fails to improve on oral antibiotics.
  • Pus collects between the tonsillar capsule and the superior constrictor muscle, so the affected tonsil and soft palate are pushed medially and downward and the uvula is displaced toward the opposite side.
  • Irritation of the adjacent internal pterygoid muscle produces trismus, and the swollen soft palate gives the characteristic muffled hot potato voice with referred otalgia and drooling.
  • Treatment is drainage by needle aspiration or incision plus antibiotics covering group A streptococcus and oral anaerobes, with airway assessment first.
  • Deviation of the uvula toward the left with trismus — correct, contralateral uvular displacement with limited mouth opening localizes a right peritonsillar collection.

Why the others are wrong

  • Tender induration beneath the jaw with a raised tongue — Ludwig angina, a bilateral cellulitis of the submandibular and sublingual spaces that usually spreads from an infected lower molar; it produces woody floor-of-mouth swelling that elevates the tongue in the midline rather than a unilateral tonsillar bulge following a sore throat.
  • Grey tonsillar exudate with posterior cervical adenopathy — infectious mononucleosis, a near-miss because it does not respond to amoxicillin (which often provokes a maculopapular rash), but its tonsillar enlargement is bilateral, with posterior cervical adenopathy, fatigue, and often splenomegaly, and it does not explain pain lateralized to the right with referred otalgia; persistent or worsening unilateral symptoms call for reassessment for a suppurative complication whatever antibiotic has been given.
  • A bulging posterior pharyngeal wall with neck stiffness — retropharyngeal abscess, which mainly affects children under 6 and presents with neck extension, torticollis, and midline posterior swelling rather than asymmetric tonsillar bulging.
  • A swollen cherry-red epiglottis with a normal oropharynx — adult supraglottitis also causes severe odynophagia, a muffled voice, and drooling with a deceptively normal-looking oropharynx, but it does not displace the uvula or cause trismus, and a sore throat that lateralizes to one side after tonsillitis fails to improve on amoxicillin points to a peritonsillar collection.

That's 1. Get 7,700+ more.

Unlock the full FirstPassPA bank: 7,700+ board-style questions, flashcards, and an AI tutor that explains every answer. Your 7-day free trial includes everything, and there's no credit card required.

Start your 7-day free trial →
🔒 Free preview limit reached

Keep reading — start your free trial

You've read your 2 free diagnosis previews. Create your free account to unlock the full Peritonsillar Abscess (Quinsy) outline — plus all 514 diagnoses, 7,700+ board-style questions, flashcards, and an AI tutor. Your 7-day free trial includes everything, and there's no credit card required.

Free to start · No credit card · Cancel anytime

Risk factors

  • Recent or recurrent tonsillitis/pharyngitis
  • Smoking
  • Prior episode of PTA
  • Chronic tonsillitis or Weber gland obstruction
  • Periodontal disease
  • Immunocompromise (less typical)

Pathophysiology

Extension of bacterial tonsillitis or obstruction of Weber salivary glands in the supratonsillar fossa leads to localized cellulitis (peritonsillitis), then abscess. Typically polymicrobial: group A Streptococcus, Fusobacterium necrophorum, Staphylococcus aureus (including MRSA), and oral anaerobes (Prevotella, Peptostreptococcus).

Clinical presentation

Symptoms

  • Severe unilateral sore throat, often worsening over 2-5 days
  • Fever, malaise
  • Odynophagia and dysphagia, drooling
  • 'Hot potato' or muffled voice
  • Trismus (difficulty opening mouth) from pterygoid muscle irritation
  • Ipsilateral ear pain (referred via CN IX/X)
  • Foul breath (fetor oris)

Signs / physical exam

  • Asymmetric tonsillar swelling with displacement of soft palate medially/inferiorly
  • Uvular deviation AWAY from the affected side
  • Tonsillar exudate possible but not required
  • Tender, sometimes fluctuant peritonsillar mass on palpation (if exam tolerated)
  • Trismus restricting mouth opening
  • Cervical lymphadenopathy on the affected side

Classic findings

Triad: severe unilateral sore throat + trismus + muffled 'hot potato' voice with uvular deviation.

Differential diagnosis

  • Peritonsillar cellulitis — Tonsillar erythema/edema without fluctuance or uvular deviation; ultrasound or CT shows no drainable collection; antibiotics alone may suffice
  • Severe acute tonsillitis — Bilateral tonsillar exudate without trismus or asymmetric swelling; oral antibiotics
  • Retropharyngeal abscess — Posterior pharyngeal wall bulge, neck stiffness with limited extension, drooling, more often in young children (<5); CT neck with contrast
  • Parapharyngeal abscess — Lateral neck swelling, trismus, medial displacement of tonsil/lateral pharyngeal wall; CT neck
  • Ludwig angina — Bilateral submandibular swelling, tongue elevation, airway risk; usually odontogenic; emergent airway control
  • Epiglottitis — Drooling, tripoding, muffled voice, severe sore throat with minimal pharyngeal findings; lateral neck XR (thumbprint) or fiberoptic exam
  • Infectious mononucleosis — Bilateral tonsillar enlargement with exudate, posterior cervical adenopathy, splenomegaly; positive heterophile
  • Tonsillar lymphoma/SCC — Persistent unilateral tonsillar enlargement without infection signs; biopsy

Diagnostic workup

Labs

  • CBC, CMP, blood cultures if febrile or toxic appearing
  • Throat culture (low yield; treatment is empiric)
  • Heterophile (Monospot) or EBV serology if mononucleosis suspected

Imaging

  • Clinical diagnosis often sufficient
  • Intraoral ultrasound — distinguishes abscess from cellulitis, guides drainage
  • CT neck with IV contrast — for atypical presentations, recurrent PTA, suspected deeper neck space involvement, pediatric patients, or when exam limited by trismus
  • MRI if vascular complication (Lemierre syndrome) suspected

Diagnostic algorithm

FeaturePeritonsillar AbscessPeritonsillar Cellulitis
Uvular deviationYes (away from affected side)Minimal/absent
TrismusMarkedMild/absent
Muffled 'hot potato' voiceYesUsually no
Fluctuant massOftenNo
Drainage yields pusYes — diagnosticNo
Imaging (US/CT)Drainable collectionInflammation only
TreatmentDrainage + antibiotics ± steroidAntibiotics alone; reassess in 24 h
Distinguishing peritonsillar abscess from peritonsillar cellulitis at the bedside.

Treatment

First-line

  • Drainage — needle aspiration OR incision and drainage by trained clinician (ENT, emergency medicine, or experienced primary care)
  • Empiric antibiotics covering streptococci and oral anaerobes — amoxicillin-clavulanate, ampicillin-sulbactam, or clindamycin × 10-14 days
  • Add IV antibiotics if toxic appearance, airway compromise, sepsis, or inability to tolerate PO
  • Analgesia, antipyretics, IV fluids if dehydrated
  • Single dose of corticosteroid (dexamethasone 10 mg IV/IM) — reduces pain and shortens hospital stay
  • Disposition: most non-toxic adults can be discharged after drainage with oral antibiotics and 24-48 h follow-up; admit if airway compromise, sepsis, immunocompromised, or inability to tolerate oral intake

Second-line / adjunct

  • ENT consultation for failed bedside drainage, recurrent PTA, or pediatric patient requiring sedation
  • Operative drainage in the OR if poorly accessible, uncooperative pediatric patient, or coagulopathy
  • Tonsillectomy ('quinsy tonsillectomy') — considered for recurrent PTA, failure of conservative therapy, or when convenient (delayed elective approach typical)
  • MRSA coverage if local prevalence high — add clindamycin, vancomycin, or linezolid

Complications

  • Airway obstruction
  • Aspiration of purulent material
  • Spontaneous abscess rupture
  • Extension to parapharyngeal or retropharyngeal space
  • Lemierre syndrome — Fusobacterium necrophorum bacteremia with internal jugular vein thrombophlebitis and septic pulmonary emboli
  • Carotid artery erosion with massive hemorrhage (rare)
  • Mediastinitis (rare)
  • Recurrent PTA (10-15%)

PANCE pearls

  • Uvular deviation toward the contralateral side + trismus + muffled voice = peritonsillar abscess until proven otherwise.
  • Needle aspiration is both diagnostic and therapeutic — pus confirms abscess vs cellulitis.
  • Always cover anaerobes — amoxicillin-clavulanate or clindamycin; penicillin alone is inadequate.
  • Persistent or worsening symptoms after PTA treatment with fever, neck pain, septic pulmonary emboli — suspect Lemierre syndrome.
  • Pediatric PTA frequently requires OR drainage under sedation/anesthesia.
  • Tonsillectomy is considered after recurrent PTA or after PTA in a patient with a history of recurrent tonsillitis (recurrence up to 40% vs 10-15% otherwise).

References

  • Clin Otolaryngol 2012 — Powell J, Wilson JA. An evidence-based review of peritonsillar abscess. Clin Otolaryngol 2012;37(2):136-145
  • AAO-HNS 2019 — Mitchell RB et al. Clinical Practice Guideline: Tonsillectomy in Children (Update). Otolaryngol Head Neck Surg 2019
  • AAFP — Galioto NJ. Peritonsillar Abscess. Am Fam Physician 2017;95(8):501-506

Practice EENT questions on FirstPassPA

Turn this outline into retention. 7,700+ board-style questions with an AI tutor that explains every answer — free to start, no card required.

Start your 7-day free trial → Get today's free question →

Educational use only. This outline is a study aid for PA students and is not medical advice or a substitute for clinical judgment. FirstPassPA is an independent study tool and is not affiliated with, endorsed by, or sponsored by NCCPA or PAEA. PANCE® and PANRE® are registered trademarks of the National Commission on Certification of Physician Assistants; End of Rotation™ is a program of the Physician Assistant Education Association.