Pus collection between tonsil capsule and pharyngeal constrictor — requires drainage plus antibiotics.
Also known as: peritonsillar abscess, PTA, quinsy
Overview
Suppurative collection in the potential space between the palatine tonsil capsule and the superior pharyngeal constrictor muscle. The most common deep neck space infection in adolescents and young adults.
Epidemiology
Annual incidence ~30/100,000 in adolescents and young adults; peak ages 15-30. Often follows acute tonsillitis or pharyngitis. Smoking and prior PTA increase risk.
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Question 1EENTEasy
A 19-year-old man has 5 days of sore throat that is now much worse on the right, with pain radiating to the right ear and difficulty swallowing his own saliva. He was started on amoxicillin 3 days ago with no improvement. Temperature is 38.7 C and heart rate is 104/min. His voice is muffled and he is drooling slightly into a cup. He is sitting comfortably and is not stridorous. Which physical examination finding is most likely to be present?
AA swollen cherry-red epiglottis with a normal oropharynx
BGrey tonsillar exudate with posterior cervical adenopathy
CA bulging posterior pharyngeal wall with neck stiffness
DTender induration beneath the jaw with a raised tongue
EDeviation of the uvula toward the left with trismus
Reveal answer & full explanation
Correct answer: E — Deviation of the uvula toward the left with trismus
AA swollen cherry-red epiglottis with a normal oropharynx
BGrey tonsillar exudate with posterior cervical adenopathy
CA bulging posterior pharyngeal wall with neck stiffness
DTender induration beneath the jaw with a raised tongue
EDeviation of the uvula toward the left with trismus✓
Why Deviation of the uvula toward the left with trismus is correct
Peritonsillar abscess is the most common deep neck space infection in adolescents and young adults and typically develops as a suppurative complication of tonsillitis that fails to improve on oral antibiotics.
Pus collects between the tonsillar capsule and the superior constrictor muscle, so the affected tonsil and soft palate are pushed medially and downward and the uvula is displaced toward the opposite side.
Irritation of the adjacent internal pterygoid muscle produces trismus, and the swollen soft palate gives the characteristic muffled hot potato voice with referred otalgia and drooling.
Treatment is drainage by needle aspiration or incision plus antibiotics covering group A streptococcus and oral anaerobes, with airway assessment first.
Deviation of the uvula toward the left with trismus — correct, contralateral uvular displacement with limited mouth opening localizes a right peritonsillar collection.
Why the others are wrong
Tender induration beneath the jaw with a raised tongue — Ludwig angina, a bilateral cellulitis of the submandibular and sublingual spaces that usually spreads from an infected lower molar; it produces woody floor-of-mouth swelling that elevates the tongue in the midline rather than a unilateral tonsillar bulge following a sore throat.
Grey tonsillar exudate with posterior cervical adenopathy — infectious mononucleosis, a near-miss because it does not respond to amoxicillin (which often provokes a maculopapular rash), but its tonsillar enlargement is bilateral, with posterior cervical adenopathy, fatigue, and often splenomegaly, and it does not explain pain lateralized to the right with referred otalgia; persistent or worsening unilateral symptoms call for reassessment for a suppurative complication whatever antibiotic has been given.
A bulging posterior pharyngeal wall with neck stiffness — retropharyngeal abscess, which mainly affects children under 6 and presents with neck extension, torticollis, and midline posterior swelling rather than asymmetric tonsillar bulging.
A swollen cherry-red epiglottis with a normal oropharynx — adult supraglottitis also causes severe odynophagia, a muffled voice, and drooling with a deceptively normal-looking oropharynx, but it does not displace the uvula or cause trismus, and a sore throat that lateralizes to one side after tonsillitis fails to improve on amoxicillin points to a peritonsillar collection.
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Extension of bacterial tonsillitis or obstruction of Weber salivary glands in the supratonsillar fossa leads to localized cellulitis (peritonsillitis), then abscess. Typically polymicrobial: group A Streptococcus, Fusobacterium necrophorum, Staphylococcus aureus (including MRSA), and oral anaerobes (Prevotella, Peptostreptococcus).
Clinical presentation
Symptoms
Severe unilateral sore throat, often worsening over 2-5 days
Fever, malaise
Odynophagia and dysphagia, drooling
'Hot potato' or muffled voice
Trismus (difficulty opening mouth) from pterygoid muscle irritation
Ipsilateral ear pain (referred via CN IX/X)
Foul breath (fetor oris)
Signs / physical exam
Asymmetric tonsillar swelling with displacement of soft palate medially/inferiorly
Uvular deviation AWAY from the affected side
Tonsillar exudate possible but not required
Tender, sometimes fluctuant peritonsillar mass on palpation (if exam tolerated)
Trismus restricting mouth opening
Cervical lymphadenopathy on the affected side
Classic findings
Triad: severe unilateral sore throat + trismus + muffled 'hot potato' voice with uvular deviation.
Differential diagnosis
Peritonsillar cellulitis — Tonsillar erythema/edema without fluctuance or uvular deviation; ultrasound or CT shows no drainable collection; antibiotics alone may suffice
Severe acute tonsillitis — Bilateral tonsillar exudate without trismus or asymmetric swelling; oral antibiotics
Retropharyngeal abscess — Posterior pharyngeal wall bulge, neck stiffness with limited extension, drooling, more often in young children (<5); CT neck with contrast
CBC, CMP, blood cultures if febrile or toxic appearing
Throat culture (low yield; treatment is empiric)
Heterophile (Monospot) or EBV serology if mononucleosis suspected
Imaging
Clinical diagnosis often sufficient
Intraoral ultrasound — distinguishes abscess from cellulitis, guides drainage
CT neck with IV contrast — for atypical presentations, recurrent PTA, suspected deeper neck space involvement, pediatric patients, or when exam limited by trismus
MRI if vascular complication (Lemierre syndrome) suspected
Diagnostic algorithm
Feature
Peritonsillar Abscess
Peritonsillar Cellulitis
Uvular deviation
Yes (away from affected side)
Minimal/absent
Trismus
Marked
Mild/absent
Muffled 'hot potato' voice
Yes
Usually no
Fluctuant mass
Often
No
Drainage yields pus
Yes — diagnostic
No
Imaging (US/CT)
Drainable collection
Inflammation only
Treatment
Drainage + antibiotics ± steroid
Antibiotics alone; reassess in 24 h
Distinguishing peritonsillar abscess from peritonsillar cellulitis at the bedside.
Treatment
First-line
Drainage — needle aspiration OR incision and drainage by trained clinician (ENT, emergency medicine, or experienced primary care)
Empiric antibiotics covering streptococci and oral anaerobes — amoxicillin-clavulanate, ampicillin-sulbactam, or clindamycin × 10-14 days
Add IV antibiotics if toxic appearance, airway compromise, sepsis, or inability to tolerate PO
Analgesia, antipyretics, IV fluids if dehydrated
Single dose of corticosteroid (dexamethasone 10 mg IV/IM) — reduces pain and shortens hospital stay
Disposition: most non-toxic adults can be discharged after drainage with oral antibiotics and 24-48 h follow-up; admit if airway compromise, sepsis, immunocompromised, or inability to tolerate oral intake
Second-line / adjunct
ENT consultation for failed bedside drainage, recurrent PTA, or pediatric patient requiring sedation
Operative drainage in the OR if poorly accessible, uncooperative pediatric patient, or coagulopathy
Tonsillectomy ('quinsy tonsillectomy') — considered for recurrent PTA, failure of conservative therapy, or when convenient (delayed elective approach typical)
MRSA coverage if local prevalence high — add clindamycin, vancomycin, or linezolid
Complications
Airway obstruction
Aspiration of purulent material
Spontaneous abscess rupture
Extension to parapharyngeal or retropharyngeal space
Lemierre syndrome — Fusobacterium necrophorum bacteremia with internal jugular vein thrombophlebitis and septic pulmonary emboli
Carotid artery erosion with massive hemorrhage (rare)
Mediastinitis (rare)
Recurrent PTA (10-15%)
PANCE pearls
Uvular deviation toward the contralateral side + trismus + muffled voice = peritonsillar abscess until proven otherwise.
Needle aspiration is both diagnostic and therapeutic — pus confirms abscess vs cellulitis.
Always cover anaerobes — amoxicillin-clavulanate or clindamycin; penicillin alone is inadequate.
Persistent or worsening symptoms after PTA treatment with fever, neck pain, septic pulmonary emboli — suspect Lemierre syndrome.
Pediatric PTA frequently requires OR drainage under sedation/anesthesia.
Tonsillectomy is considered after recurrent PTA or after PTA in a patient with a history of recurrent tonsillitis (recurrence up to 40% vs 10-15% otherwise).
References
Clin Otolaryngol 2012 — Powell J, Wilson JA. An evidence-based review of peritonsillar abscess. Clin Otolaryngol 2012;37(2):136-145
AAO-HNS 2019 — Mitchell RB et al. Clinical Practice Guideline: Tonsillectomy in Children (Update). Otolaryngol Head Neck Surg 2019
AAFP — Galioto NJ. Peritonsillar Abscess. Am Fam Physician 2017;95(8):501-506
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