Confusable diagnoses · PANCE / PANRE

Subdural Hematoma vs Epidural Hematoma

Subdural Hematoma and Epidural Hematoma are easy to mix up on the boards. Here's a side-by-side comparison — presentation, workup, imaging, and first-line treatment — drawn from our full outlines.

Subdural Hematoma vs Epidural Hematoma at a glance

  • Subdural Hematoma: Bleeding between dura and arachnoid from torn bridging veins; crescent-shaped on CT.
  • Epidural Hematoma: Arterial bleeding between skull and dura, classically from middle meningeal artery injury.
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Side-by-side comparison

FeatureSubdural HematomaEpidural Hematoma
At a glanceBleeding between dura and arachnoid from torn bridging veins; crescent-shaped on CT.Arterial bleeding between skull and dura, classically from middle meningeal artery injury.
Classic presentationCrescentic (concave/'moon-shaped') extra-axial collection on CT that crosses suture lines. Acute = hyperdense (white), subacute = isodense (may be subtle),…Lucid interval after temporal trauma + ipsilateral blown pupil + contralateral hemiparesis = uncal herniation from expanding EDH.; Head trauma with brief loss…
Workup / key labsCBC, platelets, PT/INR, PTT — anticoagulation common in this population; BMP, LFTs; Type and screen if surgical intervention likelyCBC, platelets, PT/INR, PTT (rule out coagulopathy); BMP, type and screen, alcohol/toxicology if indicated
ImagingNon-contrast head CT — first-line, identifies acute SDH easily; Subacute (isodense) SDH may be missed on CT; contrast or MRI helpful; MRI — most sensitive for…Non-contrast head CT — biconvex (lens-shaped) hyperdense collection limited by suture lines, often with adjacent skull fracture; CT brain windows + bone…
First-line treatmentABCs; intubate if GCS ≤8; Reverse anticoagulation: warfarin → 4-factor PCC + vitamin K 10 mg IV; DOACs → idarucizumab (dabigatran) or andexanet alfa /…ABCs, cervical spine immobilization; Intubation if GCS ≤8 or airway compromise; Manage ICP: head of bed 30°, normocapnia (PaCO2 35-40), hypertonic saline (3%)…

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Educational use only. This outline is a study aid for PA students and is not medical advice or a substitute for clinical judgment. FirstPassPA is an independent study tool and is not affiliated with, endorsed by, or sponsored by NCCPA. PANCE® and PANRE® are registered trademarks of the National Commission on Certification of Physician Assistants.