Confusable diagnoses · PANCE / PANRE

Ischemic Stroke vs Hemorrhagic (Intracerebral) Stroke

Ischemic Stroke and Hemorrhagic (Intracerebral) Stroke are easy to mix up on the boards. Here's a side-by-side comparison — presentation, workup, imaging, and first-line treatment — drawn from our full outlines.

Ischemic Stroke vs Hemorrhagic (Intracerebral) Stroke at a glance

  • Ischemic Stroke: Acute focal neurologic deficit from arterial occlusion causing brain infarction.
  • Hemorrhagic (Intracerebral) Stroke: Non-traumatic bleeding into brain parenchyma; higher mortality than ischemic stroke.
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Side-by-side comparison

FeatureIschemic StrokeHemorrhagic (Intracerebral) Stroke
At a glanceAcute focal neurologic deficit from arterial occlusion causing brain infarction.Non-traumatic bleeding into brain parenchyma; higher mortality than ischemic stroke.
Classic presentationSudden onset focal deficit referable to a single vascular territory; NIHSS quantifies severity (0-42).; Sudden, focal neurologic deficit: unilateral weakness,…Hypertensive ICH classically in basal ganglia (putamen most common), thalamus, pons, or cerebellum. ICH score predicts 30-day mortality.; Sudden focal…
Workup / key labsClinical syndrome of acute focal neurologic deficit with imaging evidence of infarction (CT hypodensity or MRI DWI restriction) and exclusion of hemorrhage.;…CBC, platelets, PT/INR, PTT — assess coagulopathy; BMP, glucose, troponin; Toxicology screen (cocaine, methamphetamine in young patients); Type and screen
ImagingNon-contrast head CT within 20 min of arrival — excludes hemorrhage (essential before tPA); CT angiography head and neck — identifies large vessel occlusion…Non-contrast head CT — high-density acute hematoma; immediately diagnostic; CT angiography — 'spot sign' (contrast extravasation) predicts hematoma expansion;…
First-line treatmenttPA dosing — alteplase 0.9 mg/kg IV (max 90 mg), 10% as bolus over 1 min, remainder over 60 min, if within 4.5 h of last known well and no contraindications…ABCs, intubation if GCS ≤8 or aspiration risk; BP control: target SBP 130-150 within first hour (INTERACT2, ATACH-2). Agents: IV nicardipine, clevidipine,…

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Educational use only. This outline is a study aid for PA students and is not medical advice or a substitute for clinical judgment. FirstPassPA is an independent study tool and is not affiliated with, endorsed by, or sponsored by NCCPA. PANCE® and PANRE® are registered trademarks of the National Commission on Certification of Physician Assistants.