Confusable diagnoses · PANCE / PANRE

Community-Acquired Pneumonia vs Influenza

Community-Acquired Pneumonia and Influenza are easy to mix up on the boards. Here's a side-by-side comparison — presentation, workup, imaging, and first-line treatment — drawn from our full outlines.

Community-Acquired Pneumonia vs Influenza at a glance

  • Community-Acquired Pneumonia: Lower respiratory tract infection acquired outside of healthcare settings.
  • Influenza: Acute viral respiratory illness from influenza A or B with seasonal epidemics and pandemic potential.
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Side-by-side comparison

FeatureCommunity-Acquired PneumoniaInfluenza
At a glanceLower respiratory tract infection acquired outside of healthcare settings.Acute viral respiratory illness from influenza A or B with seasonal epidemics and pandemic potential.
Classic presentationLobar consolidation with bronchial breath sounds and egophony classically points to S. pneumoniae; bullous myringitis with patchy infiltrates suggests…Abrupt onset (over hours) of fever, chills, myalgia, headache, fatigue; Respiratory: dry cough, sore throat, nasal congestion/rhinorrhea; GI symptoms…
Workup / key labsCBC (leukocytosis with left shift), BMP, lactate, procalcitonin (helps de-escalate antibiotics); Blood cultures × 2 if severe, ICU admission,…Often clinical diagnosis during peak season in otherwise well outpatients; Rapid influenza diagnostic tests (RIDT) — point-of-care, modest sensitivity…
ImagingChest radiograph (PA and lateral) — REQUIRED to diagnose pneumonia; lobar consolidation, interstitial infiltrate, or cavitation; CT chest if non-resolving,…Chest radiograph if hypoxia, focal findings, or worsening symptoms — to exclude primary viral pneumonia or secondary bacterial pneumonia; CT chest if…
First-line treatmentOutpatient, no comorbidities, no recent antibiotics: amoxicillin 1 g TID OR doxycycline 100 mg BID OR macrolide (azithromycin, clarithromycin) if local…Antivirals — start ASAP for symptomatic patients (ideally within 48 h of onset):; Oseltamivir 75 mg BID × 5 days (oral; renal dose adjust) — most widely used;…

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Educational use only. This outline is a study aid for PA students and is not medical advice or a substitute for clinical judgment. FirstPassPA is an independent study tool and is not affiliated with, endorsed by, or sponsored by NCCPA. PANCE® and PANRE® are registered trademarks of the National Commission on Certification of Physician Assistants.